Women's Health & Fertility
Couples TTC & cycle-trackers optimizing reproductive health.
Oocyte Mitochondrial Optimization
Advanced ID: womens-health-advanced
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Enhance oocyte quality, endometrial receptivity, and implantation success through mitochondrial support, hormone regulation, and targeted pharmacological adjuncts.
Rx Components
- CoQ10 (Ubiquinol) – 200–400 mg/day
- NMN – 250–500 mg/day
- Acetyl-L-Carnitine – 1000 mg/day
- DHEA – 25 mg/day (monitor and cycle)
- Bioidentical Progesterone – 100–200 mg transdermal or oral, days 14–28
- Omega-3 (EPA/DHA) – 2000 mg/day
- L-Arginine – 3–6 g/day
- Vitamin E – 400 IU/day
- Low-dose Aspirin – 81 mg/day (if advised)
Targeted Integration
| Role | Type | Components | Rationale |
|---|---|---|---|
| Mitochondrial Biogenesis | Cellular Energy Enhancement |
| Supports ATP generation and mitochondrial DNA integrity critical for egg viability, particularly in women over 35. |
| Estrogen-Progesterone Balance | Hormonal Rhythm Regulation |
| Stabilizes luteal phase, supports implantation, and modulates estrogen dominance or age-related depletion. |
| Endometrial Environment Optimization | Implantation Support |
| Improves uterine blood flow, reduces microclotting risk, and enhances nutrient delivery to endometrial tissue. |
Administration
- NMN and CoQ10 in morning with fat-containing meal
- Carnitine and DHEA split across morning and lunch
- Progesterone during luteal phase (consult provider)
- Aspirin and Omega-3 with breakfast
- Vitamin E and L-Arginine in divided doses AM/PM
Mechanism of Action
- NMN and CoQ10 enhance mitochondrial density and repair
- DHEA boosts androgen precursors to support folliculogenesis
- L-Arginine increases uterine blood flow via nitric oxide pathways
- Progesterone stabilizes luteal phase and supports embryo attachment
Cycle & Duration
- 3-month preconception cycle minimum
- Discontinue DHEA and Aspirin post-ovulation if conception confirmed
Synergies & Stack Partners
- Embryo transfer or natural TTC timed with follicular scans
- Acupuncture during implantation window
- HRV tracking to correlate stress with luteal performance
Contraindications & Side Effects
- DHEA may cause androgenic symptoms (acne, hair loss)
- Aspirin may increase bleeding risk—monitor closely
- Progesterone requires individual titration—check labs
Monitoring
- Hormone panel: AMH, estradiol, progesterone, DHEA-S
- Ultrasound for follicle maturation and endometrial thickness
- Optional: mitochondrial function markers or egg reserve assessments
References
- Bentov, Y. et al. (2010). The effect of CoQ10 on oocyte quality. Fertil Steril.
- Turi, A. et al. (2019). NAD+ boosters and ovarian aging. Cell Metab.
- Casson, P. R. et al. (2000). DHEA and ovarian response. J Assist Reprod Genet.
- Check, J. H. et al. (1996). Low-dose aspirin and pregnancy rates. Fertil Steril.
Hormonal Rhythm Foundation
Beginner ID: womens-health-beginner
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Support menstrual cycle regularity, reduce PMS symptoms, and enhance ovulatory health through foundational micronutrients and gentle adaptogens.
Rx Components
- Myo-Inositol – 2000 mg twice daily
- Vitamin D3 – 2000 IU with breakfast
- Magnesium Glycinate – 300 mg in the evening
- Vitamin B Complex – 1 cap/day with meal
- Chasteberry (Vitex agnus-castus) – 20–40 mg/day
- Omega-3 (DHA/EPA blend) – 1000 mg/day
Administration
- Myo-Inositol: AM + PM, away from food
- Vitamin D3: with fat-containing breakfast
- Magnesium: post-dinner to aid relaxation and cycle regulation
- Vitex: take in morning daily (skip during active bleeding if needed)
- Omega-3 and B Complex: with main meal
Mechanism of Action
- Myo-Inositol improves insulin sensitivity and ovarian follicle signaling
- Vitex modulates prolactin and supports progesterone production
- Magnesium and B vitamins support neurotransmitter and hormone balance
- Omega-3s reduce inflammatory prostaglandins affecting cycle and implantation
Cycle & Duration
- 3–6 month commitment for hormone rhythm effects
- Track ovulation (via BBT or LH strips) monthly to assess changes
Synergies & Stack Partners
- Reduce caffeine and alcohol during luteal phase
- Consistent sleep-wake cycles to support circadian-hormonal sync
- High-fiber, anti-inflammatory diet (flax, leafy greens, berries)
Contraindications & Side Effects
- Vitex may cause cycle shortening or acne in some users
- High-dose Vitamin D should be monitored via blood test after 2–3 months
- Myo-Inositol can cause mild GI upset initially—start slow
Monitoring
- Track menstrual cycle length, PMS severity, ovulation window
- Optional: serum D3 and ferritin levels after 8–12 weeks
- Subjective log of mood, skin, and energy across cycle phases
References
- Genazzani, A. D. et al. (2018). Myo-inositol and D-chiro inositol in PCOS. Gynecol Endocrinol.
- Wuttke, W. et al. (2003). Vitex agnus-castus in PMS and menstrual disorders. Phytomedicine.
- Rosanoff, A. et al. (2012). Magnesium and women’s hormonal health. Magnes Res.
- Gaskins, A. J. et al. (2012). Omega-3 fatty acids and reproductive health. J Clin Endocrinol Metab.
Ovulatory Resilience Protocol
Intermediate ID: womens-health-intermediate
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Enhance follicular development, luteal sufficiency, and implantation environment using hormone-modulating nutraceuticals and gentle pharmaceuticals.
Rx Components
- Myo-Inositol – 2000 mg twice daily
- Berberine – 500 mg with main meals
- Vitex (Chaste Tree Extract) – 40 mg/day
- Vitamin B6 (P5P) – 50 mg/day
- Magnesium Glycinate – 300 mg/day
- CoQ10 (Ubiquinol preferred) – 100–200 mg/day
- L-Arginine – 3 g/day (optional for uterine blood flow)
Targeted Integration
| Role | Type | Components | Rationale |
|---|---|---|---|
| Insulin Sensitivity Modulation | Metabolic Support |
| Improves ovarian function by enhancing insulin sensitivity and reducing hyperandrogenism in PCOS cases. |
| Progesterone Support | Luteal Phase Optimization |
| Improves corpus luteum health and supports progesterone production in the second half of the cycle. |
Administration
- Berberine with meals, cycle days 1–14 if targeting ovulation
- Vitex and B6 daily, morning preferred
- CoQ10 and Magnesium with meals
- L-Arginine split dose AM/PM for vascular benefit
Mechanism of Action
- Berberine and Myo-Inositol modulate insulin and ovarian signaling
- B6 and Magnesium aid steroidogenesis and neurotransmitter balance
- Vitex supports dopaminergic suppression of prolactin
- CoQ10 enhances mitochondrial function in oocytes
Cycle & Duration
- Use consistently for 3–6 cycles
- Optional: luteal progesterone testing after 2 months
Synergies & Stack Partners
- Cycle tracking with temperature + LH strips for precision
- Weight-neutral resistance training to improve insulin response
- Seed cycling or flax-lignan blend to balance estrogens
Contraindications & Side Effects
- Berberine may cause GI discomfort or lower blood pressure
- High B6 (>100 mg/day) can cause neuropathy long term
- Vitex may interfere with other hormone therapies—consult provider
Monitoring
- Track ovulation and luteal phase length
- Optional: Day 21 progesterone or mid-luteal test
- Subjective markers: breast tenderness, spotting, sleep, cervical fluid
References
- Nestler, J. E. et al. (2005). Insulin-sensitizers and PCOS. NEJM.
- Carmichael, H. et al. (2019). Coenzyme Q10 in reproductive aging. Fertil Steril.
- Wuttke, W. et al. (2003). Vitex agnus-castus in gynecology. Phytomedicine.
- Miller, R. K. et al. (2003). Vitamin B6 and hormone modulation. Am J Clin Nutr.