Longevity & Anti-Aging
Mid-life professionals focused on graceful aging and lifespan extension.
Multi-Pathway Longevity Protocol
Advanced ID: longevity-advanced
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Simultaneously activate core longevity mechanisms—senolysis, mitochondrial renewal, telomerase support, and tissue regeneration—for comprehensive anti-aging intervention.
Rx Components
- Fisetin – 500 mg/day for 2 days/month (pulse)
- Quercetin – 500 mg twice daily during pulse
- Dasatinib – 100 mg/day for 2 days/month (prescription only)
- NMN – 300–500 mg/day
- Spermidine – 1–3 mg/day
- PQQ – 10–20 mg/day
- CoQ10 (Ubiquinol) – 200 mg/day
- Epitalon – 5–10 mg subcutaneously at night for 10–20 days/month
- GHK-Cu – topical or subcutaneous, daily for 2 weeks/month
- BPC-157 – 200 mcg subcutaneously daily or as needed
Targeted Integration
| Role | Type | Components | Rationale |
|---|---|---|---|
| Senolytic & Cellular Renewal | Senotherapeutic Pulse |
| Removes senescent cells that drive inflammaging and impair tissue regeneration. |
| Hormesis & NAD+ Optimization | Mitochondrial Stress Priming |
| Activates longevity pathways (SIRT1/AMPK) and supports mitochondrial health under mild stress. |
| Peptide-Based Tissue Regeneration | Anabolic-Anti-Fibrotic Signaling |
| Modulates telomerase activity, supports DNA repair, and improves tissue homeostasis. |
Administration
- Dasatinib/Fisetin/Quercetin pulsed together under guidance monthly
- NMN + PQQ in the morning; CoQ10 with fatty meals
- Spermidine in the evening with food
- Epitalon and BPC-157 subcutaneous administration in cycles
- GHK-Cu either topically (skin) or SC for systemic anti-aging
Mechanism of Action
- Senolytics clear SASP-producing senescent cells
- NMN and PQQ enhance NAD+ and mitochondrial biogenesis
- Epitalon activates telomerase and modulates pineal gland output
- GHK-Cu and BPC-157 support tissue regeneration and ECM remodeling
Cycle & Duration
- 6–8 week supplementation with monthly senolytic pulse
- Peptide cycles: 10–20 days on, 10–20 days off
Synergies & Stack Partners
- Zone 2 cardio to support mitochondrial health
- Heat + cold exposure alternating weekly
- Low-protein fasting mimicking diet 3–5 days/month
Contraindications & Side Effects
- Dasatinib must be supervised; risk of myelosuppression
- Epitalon may affect melatonin rhythms—dose at night
- PQQ at high doses may induce oxidative stress in sensitive individuals
Monitoring
- Track subjective aging markers (energy, skin elasticity, recovery time)
- Advanced labs: DNA methylation clock, NAD+/NADH ratio, CRP, insulin, ALT/AST
- Pulse oximeter and HRV during peptide cycles
References
- Zhu, Y. et al. (2015). Senolytics improve physical function. Aging Cell.
- Poljsak, B. et al. (2013). NAD+, sirtuins, and aging. J Aging Res.
- Khavinson, V. K. et al. (2011). Epitalon and lifespan extension. Neuro Endocrinol Lett.
- Pickart, L. et al. (2008). GHK-Cu and skin regeneration. J Biomater Sci.
- Sibilla, S. et al. (2017). Spermidine and lifespan extension. Nat Cell Biol.
Longevity Fundamentals Protocol
Beginner ID: longevity-beginner
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Lay the foundation for cellular resilience, mitochondrial function, and systemic healthspan extension through accessible, evidence-based compounds.
Rx Components
- Magnesium L-Threonate – 144 mg elemental daily
- Trans-Resveratrol – 250–500 mg in AM
- Vitamin D3 + K2 – 2000 IU + 100 mcg daily
- Fish Oil (High DHA/EPA) – 1–2 g/day
- Astaxanthin – 4–8 mg/day with fat-containing meal
- CoQ10 (Ubiquinol preferred) – 100–200 mg/day
Administration
- Magnesium L-Threonate split into two doses (AM/PM)
- Resveratrol in the morning with fat for absorption
- D3+K2 with largest meal of day
- Fish oil with meals to improve uptake
- Astaxanthin post-lunch for photoprotection and antioxidant effect
- CoQ10 with any meal containing fats
Mechanism of Action
- Magnesium L-Threonate supports neuroplasticity and synaptic density
- Resveratrol activates SIRT1 and mimics caloric restriction pathways
- Vitamin D3 regulates over 1000 genes related to immune and bone health
- Fish oil improves lipid profile and reduces systemic inflammation
- Astaxanthin scavenges ROS and protects cell membranes from oxidative stress
- CoQ10 fuels mitochondrial ATP production and supports cardiac function
Cycle & Duration
- Continuous, with seasonal bloodwork check-ins every 3–6 months
Synergies & Stack Partners
- Zone 2 aerobic exercise 3–4x/week
- Time-restricted eating to improve mitochondrial stress signaling
- Minimize added sugar and ultra-processed food intake
Contraindications & Side Effects
- Vitamin D overdose risk—monitor serum 25(OH)D
- Fish oil can thin blood—caution pre-surgery
- Resveratrol may interact with anticoagulants
Monitoring
- Track energy, sleep quality, and mood monthly
- Annual check: CRP, lipid panel, 25(OH)D, and CoQ10 levels
References
- Liu, G. Y. et al. (2016). Magnesium and aging. Neuropharmacology.
- Baur, J. A. et al. (2006). Resveratrol improves health and survival in mice. Nature.
- Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med.
- Calder, P. C. (2017). Omega-3 fatty acids and inflammation. Proc Nutr Soc.
- Park, J. S. et al. (2010). Astaxanthin: Antioxidant and anti-inflammatory. J Med Food.
- Crane, F. L. (2001). Biochemical functions of CoQ10. J Am Coll Nutr.
Cellular Rejuvenation Protocol
Intermediate ID: longevity-intermediate
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Promote mitochondrial biogenesis, optimize cellular repair pathways, and initiate gentle senolytic activity to reduce biological age markers.
Rx Components
- PQQ – 10–20 mg/day
- CoQ10 (Ubiquinol) – 100–200 mg/day
- Nicotinamide Riboside (NR) – 250–300 mg/day
- Fisetin – 100 mg/day or 500 mg/day for 2-day pulse monthly
- Quercetin – 500 mg/day
- Trans-Resveratrol – 250–500 mg with fat-containing breakfast
- Curcumin (Bioavailable Form) – 500 mg/day
Targeted Integration
| Role | Type | Components | Rationale |
|---|---|---|---|
| Mitochondrial Support | Nutraceutical Stack |
| Enhances mitochondrial biogenesis and ATP output, crucial for cellular vitality and metabolic efficiency. |
| DNA Stability & Autophagy | Sirtuin Activators + Polyphenols |
| Upregulates sirtuin pathways and promotes senolytic activity, facilitating removal of damaged cells. |
Administration
- Take PQQ, NR, CoQ10 with morning meal
- Fisetin and Quercetin together on pulse days or daily based on tolerance
- Resveratrol and Curcumin with fatty meal to enhance bioavailability
Mechanism of Action
- NR boosts NAD+, essential for sirtuin activity and DNA repair
- PQQ stimulates growth of new mitochondria
- Fisetin and Quercetin help clear senescent cells
- Curcumin reduces systemic oxidative stress and modulates NF-κB
Cycle & Duration
- Daily supplementation with monthly senolytic pulses for Fisetin
- 8–12 weeks minimum for mitochondrial function markers to shift
Synergies & Stack Partners
- 12–14 hr nightly fasting window to support autophagy
- Heat exposure (sauna) and cold exposure 2–3x/week
- Strength training to drive mitochondrial turnover
Contraindications & Side Effects
- High-dose NR may disturb methylation in sensitive individuals
- Curcumin can interact with anticoagulants
- Fisetin/Quercetin may cause headache or nausea when pulsed at high doses
Monitoring
- Track energy, skin clarity, cognitive sharpness
- Optional: NAD+ levels, inflammatory markers (CRP, IL-6), telomere length annually
References
- Cheng, Y. et al. (2019). Senolytics improve physical function and increase lifespan. Nat Med.
- Rollo, C. D. et al. (2007). PQQ and mitochondrial health. Exp Gerontol.
- Canto, C. et al. (2012). NAD+ and sirtuins in aging. Cell Metab.
- Aggarwal, B. B. et al. (2007). Curcumin: the Indian solid gold. Adv Exp Med Biol.
- Yousefzadeh, M. J. et al. (2018). Fisetin is a senotherapeutic. EBioMedicine.