Immune & Inflammation
Autoimmune sufferers & chronic-inflammation folk dialing in immune balance.
Immunosenescence and Inflammation Reversal
Advanced ID: immune-advanced
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Target chronic low-grade inflammation (inflammaging), improve immune cell function, and reverse signs of immunosenescence using advanced compounds with mitochondrial and epigenetic effects.
Rx Components
- Urolithin A – 500 mg/day
- NMN – 250 mg in morning
- Quercetin Phytosome – 500 mg/day
- Thymosin Alpha-1 – 1.5 mg subcutaneous, 2–3x/week
- LL-37 – 100 mcg subcutaneous, 2x/week (if supervised)
- SPMs – 500–1000 mg/day
- Vitamin D3 + K2 – 5000 IU + 180 mcg/day
- Omega-3 EPA/DHA – 2–3 g/day
Targeted Integration
| Role | Type | Components | Rationale |
|---|---|---|---|
| Inflammaging Suppression | Mitochondrial Immuno-Rejuvenation |
| Targets senescent cell burden and enhances mitochondrial autophagy (mitophagy), improving systemic immune resilience. |
| T-Cell Activation and Regulation | Peptide Immunotherapy |
| Restores naive T-cell production and enhances host defense peptides for infection control and immune balance. |
| Systemic Inflammation Resolution | Lipid Mediator Modulation |
| Specialized pro-resolving mediators help terminate chronic inflammation without immune suppression. |
Administration
- NMN and Urolithin in morning to support circadian mitochondrial rhythm
- Quercetin with food for absorption
- Thymosin Alpha-1 in upper arm/abdomen SC
- LL-37 to be administered under medical guidance due to immune potency
- SPMs with or after food
- Vitamin D3 with largest fat-containing meal
Mechanism of Action
- Urolithin A induces mitophagy, improving energy and reducing ROS in immune cells
- Thymosin Alpha-1 enhances T-cell maturation and viral resistance
- SPMs resolve inflammation by binding to ALX/FPR2 receptors
- LL-37 modulates immune response via TLRs and antimicrobial pathways
- NMN supports NAD⁺-driven immune metabolism and SIRT1 activation
Cycle & Duration
- 12–16 weeks per protocol; taper peptides under guidance
- Monitor inflammatory and immune markers pre/post
Synergies & Stack Partners
- Senolytic pulsing (e.g. Fisetin + Quercetin monthly)
- Low-impact aerobic exercise to improve lymphatic flow
- Red light therapy on thymus area (chest) for immune activation
Contraindications & Side Effects
- LL-37 is antimicrobial but can aggravate autoimmune conditions
- Thymosin Alpha-1 may cause mild flu-like symptoms post-injection
- SPMs are generally well tolerated but should be sourced from verified suppliers
Monitoring
- Track hs-CRP, IL-6, CD4/CD8 ratio, and NK cell activity
- Monitor subjective changes in inflammation, fatigue, resilience to infection
- Optional: Epigenetic age (e.g. TruAge, DunedinPACE) and immune cell methylation clocks
References
- Ryu, D. et al. (2016). Urolithin A induces mitophagy. Nat Med.
- Chiappelli, F. (2006). Immune-modulatory effects of Thymosin Alpha-1. Biomed Pharmacother.
- Serhan, C. N. (2014). Pro-resolving lipid mediators. Nature.
- Brogden, K. A. (2005). LL-37: multifunctional antimicrobial peptide. Nat Rev Microbiol.
- Yoshino, J. et al. (2021). NAD⁺ boosters and immunometabolism. Science.
Immune Resilience Foundation
Beginner ID: immune-beginner
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Support innate immune function, reduce baseline inflammation, and build resilience through foundational nutrients and botanical compounds.
Rx Components
- Vitamin D3 – 2000 IU/day with fat-containing meal
- Zinc Picolinate – 15–30 mg/day
- Vitamin C (Buffered) – 500 mg twice daily
- Quercetin – 250 mg twice daily
- NAC (N-Acetyl Cysteine) – 600 mg twice daily
- Omega-3 (EPA/DHA) – 1000 mg combined/day
Administration
- Vitamin D with breakfast or lunch for absorption
- Zinc away from iron or calcium supplements
- Vitamin C and Quercetin with meals
- NAC on empty stomach, morning and evening
- Omega-3 with meals to reduce fishy burps
Mechanism of Action
- Vitamin D modulates innate immunity via antimicrobial peptides
- Zinc is essential for white blood cell function and antiviral defense
- Vitamin C supports neutrophil migration and oxidative defense
- Quercetin is a flavonoid with mast cell-stabilizing and anti-viral properties
- NAC replenishes glutathione, the body’s master antioxidant
- Omega-3s shift eicosanoid production away from pro-inflammatory pathways
Cycle & Duration
- Consistent daily use for 12 weeks, reassess micronutrient levels
- Pulse NAC 5 days on, 2 days off if long-term
Synergies & Stack Partners
- Meditation and deep breathing for vagal tone and inflammation control
- Anti-inflammatory diet: rich in leafy greens, berries, turmeric, and olive oil
- Hydration and daily light exposure to regulate circadian immune signals
Contraindications & Side Effects
- Excessive Vitamin D can raise calcium levels—test every 3 months
- Zinc can cause nausea if taken on an empty stomach
- High-dose NAC may thin blood or interact with medications
Monitoring
- Track energy levels, frequency of infections, and recovery time
- Optional: CRP and 25(OH)D blood levels every 3–6 months
- Subjective: sleep quality, inflammation-related joint/muscle pain
References
- Aranow, C. (2011). Vitamin D and the immune system. J Investig Med.
- Read, S. A. et al. (2019). The role of zinc in antiviral immunity. Curr Opin Clin Nutr Metab Care.
- Hemilä, H. (2017). Vitamin C and respiratory infections. Nutrients.
- Colunga Biancatelli, R. M. L. et al. (2020). Quercetin and vitamin C: Synergistic therapy. Front Immunol.
- Rushworth, G. F. et al. (2014). NAC and its role in immunity. J Clin Pharm Ther.
Adaptive Immunity Optimization
Intermediate ID: immune-intermediate
Note: Every protocol follows the "low and slow" principle. Don't add everything at once. Start with one element, observe how your body reacts, and layer gradually. Everyone's system is unique—build up at your own pace.
Overview
Enhance adaptive immune regulation, cytokine balance, and cellular defense pathways using targeted nutraceuticals and off-label immunonutrients.
Rx Components
- Curcumin Phytosome – 500 mg twice daily
- Boswellia Extract (AKBA-standardized) – 300 mg twice daily
- EGCG (from Green Tea Extract) – 150 mg/day
- NAC – 600 mg twice daily
- S-Acetyl Glutathione – 250 mg/day
- Beta Glucans (1,3/1,6) – 250 mg/day
- Reishi Mushroom Extract – 1000 mg/day
Targeted Integration
| Role | Type | Components | Rationale |
|---|---|---|---|
| Cytokine Modulation | Botanical Immunoregulation |
| These compounds help modulate NF-κB and inflammatory cytokines like TNF-α and IL-6. |
| Glutathione Support | Antioxidant Defense |
| Supports endogenous glutathione levels and cellular redox homeostasis critical for immune response. |
Administration
- Curcumin and Boswellia with fatty meals to improve absorption
- EGCG away from meals for best bioavailability
- NAC between meals or on empty stomach
- Glutathione with or without food
- Beta Glucans and Reishi in morning for immune priming
Mechanism of Action
- Curcumin and Boswellia inhibit NF-κB and COX enzymes
- EGCG suppresses pro-inflammatory cytokines and viral replication
- Beta Glucans activate macrophages and NK cells
- Reishi modulates T helper cell balance and boosts sIgA
- Glutathione regulates oxidative stress and supports immune cell metabolism
Cycle & Duration
- 6–12 weeks with re-evaluation of inflammation markers
- Consider pulsing mushrooms or botanicals 5 days on, 2 off
Synergies & Stack Partners
- Infrared sauna or Epsom salt baths to support detox pathways
- Fermented foods or probiotic rotation to enhance gut-immune axis
- Low-histamine diet if prone to allergies or mast cell activation
Contraindications & Side Effects
- Curcumin can thin blood and interact with anticoagulants
- EGCG in high doses may stress liver—monitor ALT/AST
- Reishi may lower blood pressure—use cautiously with antihypertensives
Monitoring
- CRP, IL-6, TNF-α if available; otherwise subjective inflammation and energy
- Track frequency of colds, allergies, or flare-ups
- Optional: immune panels (e.g. T-reg/CD4/CD8 ratio) in functional labs
References
- Chainani-Wu, N. (2003). Safety and anti-inflammatory activity of curcumin. Altern Med Rev.
- Sengupta, K. et al. (2008). Boswellia extract reduces inflammation. J Int Med Res.
- Katiyar, S. K. (2003). EGCG and inflammation. Int J Oncol.
- Vetvicka, V. et al. (2014). Beta glucan: immunomodulator. Biomed Pap.
- Wang, J. et al. (2012). Reishi and immune regulation. J Ethnopharmacol.